Table 3 qRT-PCR results at week 13.

From: Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy

Gene/house-keeping gene

Groups

Sham

CKD

CKD + losartan

CKD + mirabegron

Myh6/Ppia

1.41 ± 0.07

1.23 ± 0.11

1.21 ± 0.07

0.76 ± 0.09*#

Myh7/Ppia

1.29 ± 0.1

1.27 ± 0.18

0.71 ± 0.12*#

1.01 ± 0.14

Myh6/Myh7

0.94 ± 0.09

1.26 ± 0.15

0.61 ± 0.13#

1.32 ± 0.31

Col1a1/Ppia

0.2 ± 0.05

0.32 ± 0.08

0.25 ± 0.04

0.19 ± 0.06

Ctgf/Ppia

0.93 ± 0.09

1.32 ± 0.15*

0.82 ± 0.08#

1.91 ± 0.24*#

Nppa/Ppia

0.42 ± 0.09

0.63 ± 0.15

0.24 ± 0.02#

0.56 ± 0.05

Nppb/Ppia

1.05 ± 0.15

1.23 ± 0.11

0.64 ± 0.09#

1.19 ± 0.16

Nox4/Ppia

1.75 ± 0.18

2.38 ± 0.20

0.57 ± 0.09*#

1.25 ± 0.13*#

Nos2/Ppia

0.95 ± 0.19

2.80 ± 0.55*

1.26 ± 0.21#

1.17 ± 0.37#

IL1/Ppia

0.77 ± 0.05

1.18 ± 0.11*

0.78 ± 0.06#

0.94 ± 0.16

IL6/Ppia

0.81 ± 0.18

2.94 ± 0.6*

0.37 ± 0.08#

0.52 ± 0.12#

Tnf-α/Ppia

0.77 ± 0.05

1.2 ± 0.1*

0.83 ± 0.09#

0.99 ± 0.12

Agtr1a/Ppia

1.55 ± 0.06

1.13 ± 0.1*

1.26 ± 0.11

0.86 ± 0.08*#

Agt/Ppia

1.32 ± 0.09

1.24 ± 0.09

1.08 ± 0.12

1.12 ± 0.14

Adrb3/Ppia

0.65 ± 0.10

0.99 ± 0.07

0.9 ± 0.1

1.08 ± 0.21

  1. Values are presented as mean ± S.E.M., *p < 0.05 vs. sham-operated group, #p < 0.05 vs. CKD group (n = 6–10, One-Way ANOVA, Holm-Sidak post hoc test).
  2. Sham sham-operated group, CKD chronic kidney disease group, Adrb3 β-3 adrenergic receptor, Agt angiotensinogen, Agtr1a angiotensin-II receptor type 1a, Col1a1 collagen type 1 alpha 1 chain, Ctgf connective tissue growth factor, IL1 interleukin-1, IL6 interleukin-6, Myh6 α-myosin heavy chain, Myh7 β-myosin heavy chain, Nos2 inducible nitric oxide synthase, Nox4 NADPH-oxidase type 4, Nppa A-type natriuretic peptide, Nppb B-type natriuretic peptide, Ppia Peptidyl prolyl isomerase A, Tnf-α tumor necrosis factor alpha. Ppia was used as a housekeeping gene for normalization.
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