Figure 5
From: A virus-free cellular model recapitulates several features of severe COVID-19
Gender-preferential pathway expression links ACE2 overexpression to worse clinical outcome in males. Measurement of the gender specific activation of the pathways associated to ACE2 overexpression identified 131 gene sets with significant gender preferential activity, with the top 30 lists shown in (a). Disease-linked genes IL1A (b,c), IL1B (d,e) and IFNW1 (f,g) also show preferential activation in males.
