Table 3 Performance of prognosis models among high-risk patients with MCI.

From: Screening and predicting progression from high-risk mild cognitive impairment to Alzheimer’s disease

Predictive dataset

Prognosis model

NRI (95% CI)

IDI (95% CI)

ADAS-13 (N = 110)

A1+ baseline MRI versus A1

0.123 (0.045, 0.664)*

0.003 (− 0.118, 0.093)

A2+ baseline MRI versus A2

− 0.062 (− 0.074, 0.391)

0.006 (− 0.172, 0.172)

A2+ ∆MRI versus A2

0.246 (0.021, 0.848)*

0.090 (− 0.094, 0.209)

MMSE (N = 92)

M1+ baseline MRI versus M1

0.177 (− 0.035, 0.902)

0.008 (− 0.085, 0.087)

M2+ baseline MRI versus M2

0.201 (− 0.046, 0.685)

0.005 (− 0.148, 0.107)

M2+ ∆MRI versus M2

0.489 (− 0.132, 0.878)

0.065 (− 0.062, 0.170)

  1. A1, ADAS-13 baseline Prognosis Model; A2, ADAS-13 longitudinal Prognosis Model; M1, MMSE baseline Prognosis Model; M2, MMSE longitudinal Prognosis Model. ADAS-13, Alzheimer Disease Assessment Scale Cognitive 13 items; MMSE, Mini mental state examination; NRI, Net Reclassification Improvement; IDI, Integrated Discrimination Improvement. Values based on the following assumptions: Risk of event = 10%.
  2. *The indices are statistically significant.
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