Figure 3

Major biological themes (pathways, upstream regulators, disease and biological functions) obtained from mapping the significantly upregulated DEGs in the spleen of chicks post infection. In IPA, only significantly enriched entities that passed a Fisher’s exact test p-value cut of 0.05 and also passes an absolute z-score cut-off of 2 or greater were visualised. Orange nodes are predicted to be activated (z-score ≥ 2), while blue nodes are predicted to be inhibited (z-score ≥ 2). Blue line: leads to inhibition, orange line: leads to activation green lines: decreased measurement.