Table 3 Comparison of DEGs response to NDV in the present study and other in vivo NDV infection studies. LFC stands for log₂ fold change.

PLCXD1

Phosphatidylinositol specific phospholipase C X domain containing 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and Harderian gland of leghorn at 6 dpi¹⁹

SLBP

Stem-loop binding protein

Consistent with spleen of Hy-line brown at 2 dpi²¹ and spleen²⁰ and trachea¹⁸ of leghorn at 2 dpi

OSTM1

Osteoclastogenesis associated transmembrane protein 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 2 dpi¹⁸

DRAM1

DNA damage regulated autophagy modulator 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and Trachea of fayoumi and leghorn at 2 dpi¹⁸

PARP12

Poly(ADP-ribose) polymerase family member 12

Consistent with spleen of Hy-line brown at 2 dpi²¹ and harderian gland at 2 and 6 dpi¹⁹, in spleen at 2 dpi²⁰ in leghorn

SNX10

Sorting nexin 10

Consistent with spleen of Hy-line brown at 2 dpi²¹ and spleen²⁰ and trachea¹⁸ of leghorn at 2 dpi

IFIT5

Interferon induced protein with tetratricopeptide repeats 5

Consistent with spleen of Hy-line brown at 2 dpi²¹ and spleen of leghorn at 1⁴⁴, 2^20,44and 6 dpi²⁰, and of fayoumi at 2 dpi²⁰

P2RX1

Purinergic receptor P2X 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and lung of fayoumi at 10 dpi¹⁷

KAZALD1

Kazal type serine peptidase inhibitor domain 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 6 dpi¹⁸

HPSE2

Heparanase 2 (inactive)

Consistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 2 dpi¹⁸

UROC1

Urocanate hydratase 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and harderian gland of leghorn at 6 dpi¹⁹

ROR1

Receptor tyrosine kinase like orphan receptor 1

Consistent with spleen of Hy-line brown at 2 dpi²¹ and lung of fayoumi at 2 dpi¹⁷

FSHR

Follicle stimulating hormone receptor

Consistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 6 dpi¹⁸

AICDA

Activation induced cytidine deaminase

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 6 dpi¹⁸

P2RY8

P2Y receptor family member 8

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and harderian gland at 6 dpi¹⁹ and trachea at 2 and 6 dpi¹⁸ in leghorn

ARHGAP15

Rho GTPase activating protein 15

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of fayoumi at 2 dpi and leghorn at 2 and 6 dpi¹⁸

ASNS

Asparagine synthetase (glutamine-hydrolyzing)

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and harderian gland of leghorn at 6 dpi¹⁹

TRIM24

Tripartite motif containing 24

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 6 dpi¹⁸

CDC42SE2

CDC42 small effector 2

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of fayoumi at 2 dpi¹⁸

BFAR

Bifunctional apoptosis regulator

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of fayoumi and leghorn at 2 dpi¹⁸

ST3GAL4

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and harderian gland of leghorn at 6 dpi under heat stress¹⁶

MYH10

Myosin heavy chain 10

Inconsistent with spleen of Hy-line brown at 2 dpi²¹ and trachea of leghorn at 6 dpi¹⁸

EPHB1

EPH receptor B1

Inconsistent with spleen of Hy-line brown²¹ and trachea of fayoumi at 2 dpi¹⁸