Figure 2 | Scientific Reports

Figure 2

From: Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice

Figure 2

The NPC1L1, ABCG5/8 TKO exhibits improved cardiac function relative to ABCG5/8 DKO littermates. ABCG5/8 DKO mice exhibit decreased ejection fraction (A) and fractional shortening (B) and an increase in both systolic (C) and diastolic volume (D) with negligible changes to stroke volume (E) and a modest decrease in heart rate (F), which is indicative of impaired cardiac function and left ventricular dilation. These impairments in cardiac function are not observed for the TKO, NPC1L1 KO or WT littermate controls. DKO—ABCG5/8 double knockout, TKO—ABCG5/8, NPC1L1 triple knockout. Data represented as group means (circles) ± SEM. WT: N = 15/ group; NPC1L1 KO: N = 20–21/group; TKO: N = 11–13/group; DKO: N = 6–12/group. Significance measured using a mixed-effects model (REML)—Tukey’s multiple comparisons test (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 relative to WT littermates). Data analyses performed blinded.

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