Figure 3
From: Molecular characterization and cell type composition deconvolution of fibrosis in NAFLD
Cell composition deconvolution of the liver bulk RNA-Seq data. (A) Combined and integrated single cell reference data set (split UMAP view). The previously published human (11) and mouse (25) data sets have been re-analyzed, re-annotated, filtered for conserved cell types in both data sets, and finally aligned. (B) Validation of cell type annotation in the combined single cell reference by cell type-specific marker genes for Cholangiocytes, Hepatocytes, Hepatic Stellate Cells, and Macrophages. (C) Correlation between predicted cell type fraction and the continuous fibrosis score (ImageScore). (D) Predicted change of cell type proportions across observed NASH fibrosis stage.
