Figure 4
From: Molecular characterization and cell type composition deconvolution of fibrosis in NAFLD
Hepatocyte-specific transcriptional up-regulation of apoptosis pathway. (A) Heatmap of cell-type specific differential expression, which is estimated by using regression based method with R package omicwas (see method for details), shown as log2 fold change per gene (rows) and cell type (columns) in NASH F3/F4 versus F0/Normal. (B) Heatmap of number of cell type-specific marker genes overlapping with disease clusters shown in Fig. 1B. (C) Cell type-specific functional annotation. Significantly enriched categories are marked with asterisk. (D) Enrichment plot of apoptosis pathway obtained from Gene Set Enrichment Analysis. Genes were ranked by the level of up-regulation (from left to right).
