Figure 2 | Scientific Reports

Figure 2

From: Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag

Figure 2

The interactions between the SCN and the HPA axis orchestrate the physiological response to the photic Zeitgeber. (a) Dynamic profiles of clock gene mRNAs, VIP, AVP, and CORT generated by the model with nominal parameters as indicated in Table 1. All components oscillate with a period of 24 h once the system gets entrained. Bmal1 mRNA oscillates almost anti-phasic to Per/Cry mRNA. mRNAs in the shell oscillate with a phase delay of 3 h compared to mRNAs in the core. White/dark patterns denote light/dark settings. (b) Experimentally determined phase relation between the representative components (left) and model predictions (right) are consistent63,64,65,66.

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