Figure 3

General inflammatory marker concentrations in non-CF (n = 20), CF unexposed (n = 10), and CF Bordetella pseudohinzii exposed (n = 10) mouse serum. MIP-2, IL-27p28, IP-10, IL-22 (a), and IL-16 (b) were significantly elevated in CF mice. Notably, IL-33 (a) is the only inflammatory marker that showed a significant baseline reduction in CF mice when compared to non-CF controls. IL-5 (a) displays a significant reduction (+) in concentration following B. pseudohinzii exposure when compared to unexposed CF counterparts. There are no other differences in inflammatory markers between unexposed and exposed CF mice, though all remain elevated as compared to non-CF controls. IL-16, KC/GRO, and MIP-1α (b–d) are displayed separately to visualize differences in scale.