Figure 4

Proinflammatory marker concentrations in untreated Non-CF (n = 4) and CF (n = 4) mice, and then following Bordetella pseudohinzii inoculation at 48 h and 2 weeks post-infection (Non-CF n = 8, CF n = 8). In Non-CF mice, there is a significant elevation in IL-6 and TNF-α, both of which remain elevated at 2 weeks post-infection. In CF mice, all but IL-2 exhibit a significant increase in serum concentration at 48 h post-infection as compared to uninfected CF controls, and drop after 2 weeks to near uninfected levels (a–d). In CF mice, IL-2 displays as light reduction post-inoculation and sharply declines 2 weeks post-infection (a). IFN-γ, IL-6, and TNF-α (b–d) are displayed separately to visualize differences in scale.