Table 5 Engineered organisms for HA production.
Organism | HAS source | HA (g/l) | Molecular weight (MDa) | Quantification method | Ref. |
|---|---|---|---|---|---|
Enterococcus faecalis | S. pyogenes | 0.69 | *** | Carbazole | |
Escherichia coli | S. pyogenes | 0.08 | *** | Carbazole | |
Escherichia coli | Human | *** | *** | *** | |
Bacillus subtilis | S. equisimilis | 0.81 | 1.2 | Carbazole | |
Lactococcus lactis | S. zooepidemicus | 0.65 | *** | HPLC | |
Bacillus subtilis | S. zooepidemicus | 0.84 | *** | Carbazole | |
Agrobacterium sp. | P. multocida | 0.3 | 0.7–2 | Carbazole | |
Escherichia coli | P. multocida | 0.55 | 1.5 | Carbazole | |
Lactococcus lactis | S. zooepidemicus | 0.59 | 0.88 | Radioimmunoassay | |
Lactococcus lactis | S. zooepidemicus | 0.11 | 2.8 | Carbazole | |
Tobacco Cells | Chlorovirus | *** | *** | *** | |
Bacillus subtilis | P. multocida | *** | 5.43 | Carbazole | |
Lactococcus lactis | S. zooepidemicus | 0.14 | 4.3 | Carbazole | |
Pichia pastoris | Xenopus laevis | 0.2 | 0.25 | Carbazole | |
Streptomyces albulus | S. zooepidemicus | 5.1 | 2 | Carbazole | |
Bacillus subtilis | S. zooepidemicus | 2.05 | 1.76 | Carbazole | |
Corynebacterium glutamicum | S. equisimilis | 0.14 | *** | CTM | |
Corynebacterium glutamicum | S. equisimilis | 5.4 | 1.28 | CTM | |
Bacillus subtilis | S. equisimilis | 0.48 | 1.95 | Carbazole | |
Kluyveromyces lactis | P. multocida | 1.89 | 2.09 | Carbazole | |
Tobacco hairy roots | Human | 0.56 | > 0.8 | ELISA KIT | This study |
