Table 2 Residual Genetic Heritability Estimates.

From: Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults

 

Residual Heritability Estimate*

Residual Heritability P-value

Variance explained by covariates*

CVD risk factors

Carotid mean IMT (mm)

0.478

2.83 × 10–17

0.399

Carotid mean IAD (mm)

0.621

3.94 × 10–22

0.410

SBP (mmHg)

0.133

0.010

0.111

DBP (mmHg)

0.142

0.004

0.252

BMI (kg/m2)#

0.500

6.99 × 10–17

0.477

Waist circumference (cm)#

0.494

7.63 × 10–18

0.133

Cognitive function

DSST

0.417

5.38 × 10–15

0.490

Retained memory

0.285

4.63 × 10–8

0.213

Working memory

0.518

2.25 × 10–17

0.280

Animal fluency

0.397

4.77 × 10–13

0.255

Time to complete trails A

0.220

6.8 × 10–06

0.437

Time to complete trails B

0.319

1.0 × 10–07

0.464

Physical function

Grip strength (kg)

0.454

5.93 × 10–18

0.711

Gait speed (m/s)

0.164

0.002

0.542

Chair stand time (s)

0.264

1.1 × 10–05

0.255

  1. *Residual heritability estimates shown range from 0–1 and demonstrate the proportion of the variance in the measure that is attributed to genetic factors after adjustment for covariates. Whereas, the variance explained by covariates is the proportion of the variance in the measure that is explained by the included covariates. Covariates for each model include: age, age2, sex, field centers, height, weight, and whether an individual currently smokes.
  2. #Weight and height not included as covariates in BMI model; weight not included as covariate in waist circumference model.
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