Table 1 Resting parameters in wild-type and endothelial nitric oxide synthase knock-out mice.

From: Short-term facilitation of breathing upon cessation of hypoxic challenge is impaired in male but not female endothelial NOS knock-out mice

Parameter

Male

Female

WT

eNOS–/–

WT

eNOS–/–

Number of mice

12

13

12

12

Age, days

78.0 ± 0.2

80.8 ± 2.2

79.0 ± 0.2

76.0 ± 2.2

Body weight, g

24.9 ± 0.5

23.7 ± 0.6

19.1 ± 0.3*

18.2 ± 0.4‡

Frequency, breaths/min

186 ± 8

185 ± 6

182 ± 4

172 ± 3

Tidal volume, ml

0.205 ± 0.005

0.196 ± 0.009

0.167 ± 0.006

0.169 ± 0.004

Minute ventilation, ml/min

37.4 ± 1.3

35.6 ± 1.3

29.9 ± 0.8

29.0 ± 1.1

Inspiratory time, sec

0.115 ± 0.002

0.113 ± 0.003

0.120 ± 0.002

0.126 ± 0.002

Expiratory time, sec

0.227 ± 0.007

0.225 ± 0.008

0.226 ± 0.007

0.240 ± 0.005

Inspiratory time/expiratory time

0.520 ± 0.016

0.509 ± 0.011

0.543 ± 0.014

0.538 ± 0.012

Inspiratory drive, ml/sec

1.82 ± 0.08

1.75 ± 0.07

1.41 ± 0.04

1.36 ± 0.05

Expiratory drive, ml/sec

0.92 ± 0.03

0.88 ± 0.03

0.75 ± 0.02

0.72 ± 0.03

Peak inspiratory flow (PIF), ml/sec

2.97 ± 0.14

2.89 ± 0.12

2.29 ± 0.06

2.28 ± 0.08

Peak expiratory flow (PEF), ml/sec

1.96 ± 0.09

1.90 ± 0.0.10

1.57 ± 0.07

1.50 ± 0.05

PIF/PEF

1.53 ± 0.05

1.56 ± 0.06

1.49 ± 0.05

1.53 ± 0.03

  1. The data are presented as mean ± SEM. WT, wild-type C57BL6 mice. eNOS–/–, endothelial nitric oxide synthase knock-out mice. There were no differences in ages, body weights and resting ventilatory parameters between male WT and eNOS–/– mice and between female WT and eNOS–/– mice (*P < 0.05, body weights, male WT versus female WT mice; and ‡P < 0.05, body weights, male eNOS–/– versus female eNOS–/– mice).
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