Table 1 Univariate analysis of outcomes grouped by exposed (gulf states) and unexposed (all other states) and then further subdivided by time period, pre and post HK.
n | Gulf states (exposed) | Other states (not exposed) | |||||
|---|---|---|---|---|---|---|---|
Pre-HK | Post-HK | P-value (Post-vs-Pre) | Pre-HK | Post-HK | P-value (Post-vs-Pre) | ||
Age | |||||||
All, mean (SD) | 451,848 | 34.7 (4.6) | 34.6 (4.6) | 0.37 | 35.4 (4.6) | 35.6 (4.7) | < 0.0001* |
< 35 (%) | 186,780 | 7439 (48.6) | 16,202 (47.5) | 0.35 | 54,749 (42.0) | 108,390 (40.1) | < 0.0001* |
35–37 (%) | 103,299 | 3500 (22.9) | 8195 (24.0) | 29,387 (22.5) | 62,217 (23.0) | ||
38–40 (%) | 91,989 | 2773 (18.1) | 6249 (18.3) | 26,937 (20.7) | 56,030 (20.8) | ||
41–42 (%) | 42,354 | 1065 (7.0) | 2331 (6.8) | 12,384 (9.5) | 26,574 (9.8) | ||
> 42 (%) | 25,409 | 536 (3.5) | 1120 (3.3) | 6921 (5.3) | 16,832 (6.2) | ||
Max FSH Level (mIU/mL), mean (SD) | 7.3 (3.7) | 7.7 (3.7) | < 0.0001 | 7.7 (4.2) | 8.3 (4.9) | < 0.0001* | |
Gravidity, mean (SD) | 1.10 (1.41) | 1.07 (1.40) | 0.09 | 1.07 (1.37) | 1.09 (1.39) | 0.0003* | |
Infertility diagnosis, (%) | |||||||
Male | 165,679 | 6877 (44.9) | 14,735 (43.2) | 0.003 | 46,690 (35.8) | 97,377 (36.1) | 0.22 |
Endometriosis | 56,514 | 3038 (19.8) | 5987 (17.6) | < 0.0001 | 17,068 (13.1) | 30,421 (11.3) | < 0.0001* |
PCOS | 62,050 | 2458 (16.1) | 5247 (15.4) | 0.11 | 17,635 (13.5) | 36,710 (13.6) | 0.63 |
DOR | 93,234 | 2882 (18.8) | 6734 (19.8) | 0.04 | 24,729 (19.0) | 58,889 (21.8) | < 0.0001* |
Tubal | 81,273 | 3735 (24.4) | 7156 (21.0) | < 0.0001 | 25,732 (19.7) | 44,650 (16.5) | < 0.0001* |
Uterine | 22,868 | 823 (5.4) | 1683 (4.9) | 0.09 | 6605 (5.1) | 13,757 (5.1) | 0.76 |
Unexplained | 55,376 | 846 (5.5) | 2387 (7.0) | < 0.0001 | 17,010 (13.1) | 35,334 (13.1) | 0.79 |
Total FSH Dosage, mean (SD) | 3046.5 (1442.8) | 3145.2 (1483.8) | 98.6 (66.2–131.0; < 0.0001) | 3112.3 (1652.7) | 3313.3 (1710.6) | #201.1 (187.4–214.8; p < 0.0001)* | |
Number of Oocytes Retrieved, mean (SD) | 12.7 (7.7) | 12.6 (7.8) | 0.994 (0.981–1.008; 0.39) | 12.5 (7.9) | 12.4 (8.0) | #0.989 (0.984–0.994; p < 0.0001)* | |
Clinical pregnancy, n (%) | |||||||
Intrauterine | 157,404 | 5682 (37.1) | 13,217 (38.8) | 1.07 (1.03–1.12; 0.001) | 43,144 (33.1) | 95,361 (35.3) | #1.10 (1.09–1.12; p < 0.0001)* |
Biochemical | 28,583 | 923 (6.0) | 2286 (6.7) | 1.12 (1.03–1.21; 0.01) | 7907 (6.1) | 17,467 (6.5) | #1.07 (1.04–1.10; p < 0.0001)* |
Pregnancy outcome, n (%) | |||||||
Live Birth | 128,889 | 4720 (30.8) | 11,006 (32.3) | 1.07 (1.03–1.12, 0.002) | 35,363 (27.1) | 77,800 (28.8) | #1.09 (1.07–1.10; p < 0.0001)* |
Abortion | 26,784 | 885 (5.8) | 2024 (5.9) | 1.03 (0.95–1.12; 0.50) | 7249 (5.6) | 16,626 (6.2) | #1.11 (1.08–1.15; p < 0.0001)* |
Weight (g), mean (SD) | 3189.1(628.6) | 3174.8 (619.9) | -14.4 (-40.7, 12.0; 0.29) | 3247.9 (615.9) | 3234.8 (613.0) | #-13.1 (-22.5, -3.8; p = 0.01)* | |
Male sex (%) | 43,817 | 1560 (51.0) | 3624 (49.9) | 0.96 (0.88–1.04; 0.33) | 11,795 (49.6) | 26,838 (50.3) | #1.03 (1.00–1.06; p = 0.06) |
