Table 1 Summary of carboplatin sensitivity of EOC cell lines across model systems.
Cell lines | 2D monolayers | 3D spheroids | 3D MDTs | Xenograft | In vivo correlation |
|---|---|---|---|---|---|
OV4453 | Sensitive | Resistant | Sensitive | Sensitive | 2D + 3D MDTs |
TOV21G | Sensitive | Resistant | Resistant | Resistant | 3D spheroids/MDTs |
OV1946 | Intermediate | Sensitive | Sensitive | Sensitive | 3D spheroids/MDTs |
OV4485 | Intermediate | Resistant | Intermediate | Intermediate | 2D + 3D MDTs |
TOV112D | Resistant | Resistant | Resistant | Resistant | 2D + 3D spheroids/MDTs |
OV90 | Resistant | Intermediate | Not performed | Intermediate | 3D spheroids |
