Table 2 Risk factors for thromboembolic events.

From: Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms

Disease

Variable

HR (95% CI)

q-value

MPN

Age at dx

2.08 (1.01–4.26)

0.045

Sex

1 (0.52–1.95)

0.993

Leukocytosis*

2.67 (1.36–5.24)

0.004

Hemoglobin

1.03 (0.93–1.13)

0.564

CVD risk factor**

1.48 (0.76–2.87)

0.249

History of thrombosis

5.24 (2.73–10.08)

< 0.001

PV

Age at dx

2.79 (0.52–15.04)

0.233

Sex

3.49 (0.63–19.24)

0.151

Hepatomegaly

19.9 (0.79–498.94)

0.069

Splenomegaly

0.58 (0.13–2.5)

0.466

Leukocytosis*

5.91 (0.74–47.08)

0.093

Hemoglobin

1.97 (1.28–3.04)

0.002

Platelet

1 (1–1.01)

0.341

CVD risk factor**

0.37 (0.05–2.73)

0.331

History of thrombosis

9.68 (2–46.88)

0.005

ET

Age at dx

1.76 (0.55–5.63)

0.342

Sex

1.2 (0.44–3.29)

0.72

Splenomegaly

3.13 (0.67–14.6)

0.15

JAK2V617F

0.48 (0.17–1.4)

0.181

Leukocytosis*

2.65 (0.45–15.62)

0.281

Platelet

1 (1–1)

0.354

CVD risk factor**

1.95 (0.61–6.2)

0.258

History of thrombosis

5.16 (1.73–15.38)

0.003

PMF

Age at dx

3.82 (0.32–45.61)

0.29

Sex

0.39 (0.03–4.85)

0.466

Hepatomegaly

1.21 (0.04–32.51)

0.911

Splenomegaly

1.29 (0.17–9.64)

0.805

JAK2V617F

0.49 (0.03–8.3)

0.621

Leukocytosis*

4.34 (0.54–34.9)

0.167

Platelet

1 (1–1)

0.823

CVD risk factor**

2.29 (0.34–15.63)

0.397

History of thrombosis

13.85 (1.2–g159.5)

0.035

  1. * Patients who had two or more cardiovascular disease risk factors; CVD risks were defined as obesity (BMI > 25), smoking, hypertension, diabetes and dyslipidemia.
  2. ** Leukocytosis was defined as WBC > 15 × 109/L.
  3. HR, Hazard ratio; CI, confidence interval; MPN, myeloproliferative neoplasms; PV, polycythemia vera; ET, essential thrombocythemia; PMF, primary myelofibrosis; dx, diagnosis; BMI, body mass index; WBC, white blood cell; CVD, cardiovascular disease.
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