Table 1 Baseline characteristics of PLA2R-negative MN and MCD.

From: Development and validation of a discrimination model between primary PLA2R-negative membranous nephropathy and minimal change disease confirmed by renal biopsy

Variables

MN (n = 200)

MCD (n = 144)

p Value

Age (years)

50 (34, 58)

31 (24, 48)

 < 0.001

Gender, n (male, %)

114 (57.0)

80 (55.6)

0.790

SBP (mmHg)

130 (120, 140)

127 (117, 135)

0.114

DBP (mmHg)

80 (76, 87)

83 (78, 90)

0.117

RBC (1012/L)

4.33 ± 0.58

4.64 ± 0.64

 < 0.001

WBC (109/L)

6.50 (4.50, 7.88)

6.2 (5.1, 7.6)

0.310

PLT (109/L)

225 (192, 265)

252 (203, 313)

0.001

Eos (109/L)

0.12 (0.08, 0.21)

0.13 (0.07, 0.23)

0.480

Eos%

2.00 (1.20, 3.00)

2.10 (1.37, 3.92)

0.230

Hb (g/L)

130.5 ± 18.1

138.9 ± 21.9

 < 0.001

MCH (pg)

30.3 (29.3, 31.4)

30.4 (29.0, 31.4)

0.878

MCHC (g/L)

333 (327, 339)

333 (326, 338)

0.515

TP (g/L)

51.0 (44.7, 58.1)

41.2 (36.4, 46.8)

 < 0.001

ALB (g/L)

28.05 (22.81, 34.38)

19.78 (16.83, 23.18)

 < 0.001

TCHO (mmol/L)

6.05 (4.95, 7.83)

10.06 (7.86, 11.93)

 < 0.001

TG (mmol/L)

1.85 (1.25, 2.67)

2.18 (1.51, 3.20)

0.018

LDL (mmol/L)

3.99 (3.11, 5.33)

7.82 (5.34, 9.66)

 < 0.001

HDL (mmol/L)

1.25 (1.05, 1.57)

1.63 (1.29, 2.05)

 < 0.001

eGFR (ml/min/1.73m2)

104.03 (90.24, 114.49)

100.16 (71.38, 118.85)

0.383

Scr (μmol/L)

68 (56, 80)

76 (61, 102)

 < 0.001

Urea (mmol/L)

4.80 (3.73, 6.02)

5.50 (3.99, 8.38)

0.001

UA (μmol/L)

310.0 (259.3, 375.3)

317.5 (261.5, 385.3)

0.650

CRP (mg/L)

0.70 (0.05, 1.90)

0.83 (0.01, 2.02)

0.563

ESR (mm/h )

29.0 (16.8, 53.0)

55.0 (33.0, 77.2)

 < 0.001

C3 (g/L)

1.29 (1.13, 1.47)

1.44 (1.26, 1.58)

 < 0.001

C4 (g/L)

0.30 (0.25, 0.35)

0.33 (0.28, 0.38)

 < 0.001

24hTP (g)

4.04 (1.92, 7.20)

6.43 (4.28, 9.04)

 < 0.001

Urine volume (L)

1.6 (1.2, 2.2)

1.2 (0.7, 1.9)

 < 0.001

Thrombosis, n (%)

1 (0.50)

5 (3.47)

0.086

  1. SBP systolic blood pressure, DBP diastolic blood pressure, RBC red blood cell, WBC white blood cell, PLT platelet, EOS eosinophil, Hb hemoglobin, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, TP total protein, ALB albumin, TC total cholesterol, TG triglyceride, LDL low density lipoprotein, HDL high density lipoprotein, eGFR estimated glomerular filtration rate, Scr serum creatinine, UA uric acid, CRP C reactive protein, ESR erythrocyte sedimentation rate, C3 complement 3, C4 complement 4, 24hTP 24 h uric total protein, thrombosis venous thrombosis of lower extremity.
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