Figure 4 | Scientific Reports

Figure 4

From: Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study

Figure 4

(A) Optical density and (B) density of intratumoral endothelial cell staining. Numeric trends indicate reduced microvessel density in TP-fed groups. (C) Lumen irregularity, calculated as: perimeter2/(4 × π × area), with a value of 1.0 indicating a perfect circle and values > 1.0 indicating increasing irregularity. (D) Ultrasound microvessel image showing blood flow through microvasculature. Yellow arrows indicate regional similarities observed by (E) immunohistochemistry staining against endothelial cells. *Indicates statistical significance (p < 0.05 by mixed-model ANCOVA with body weight at tumor detection as a covariate, n = 5/dietary group).

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