Table 4 Univariate and multivariate analyses of progression-free survival using a Cox proportional hazards model in patients with cervical adenocarcinoma.

From: P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway

Factor

Patients

Univariate analysis

Multivariate analysis

n = 82

HR

95% CI

p value

HR

95% CI

p value

Age (years)

< 60

58

0.552

0.236–1.293

0.171

   

≥ 60

24

ref

     

FIGO stage

< IIB

58

0.194

0.081–0.464

< 0.0001

0.85

0.252–2.867

0.793

≥ IIB

24

ref

  

ref

  

Histology

Non-gastric type

69

0.819

0.277–2.422

0.819

   

Gastric type

13

ref

     

Tumor size (mm)

< 40

50

0.135

0.050–0.369

0.0001

0.161

0.036–0.719

0.017

≥ 40

32

ref

  

ref

  

Metastasis Pelvic Lymph node

Negative

65

0.379

0.162–0.889

0.026

0.553

0.165–1.858

0.338

Positive

17

ref

  

ref

  

Metastasis Paraaortic Lymph node

Negative

79

0.209

0.061–0.707

0.012

ref

  

Positive

3

ref

  

1.828

0.292–11.466

0.519

Metastasis distance

Negative

81

0.078

0.009–0.644

0.018

0.503

0.047–5.320

0.568

Positive

1

ref

  

ref

  

Metastasis LSVI

No

29

0.453

0.087–2.353

0.004

0.065

0.007–0.597

0.016

Yes

39

ref

  

ref

  

p16INK4A expression

Negative

22

ref

  

ref

  

Positive

60

0.376

0.162–0.873

0.023

0.965

0.331–2.812

0.948

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