Table 1 Sequence and properties of the membrane-active peptides used.

From: Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity

Peptide

Source

Sequence

Residue

Net charge

Melittin

Insect venom

GIGAVLKVLT TGLPALISWI KRKRQQ

26

 + 6

CM15

Synthetic hybrid

KWKLFKKIGA VLKVL

15

 + 6

LL-37

Human (skin, intestine, etc.)

LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES

37

 + 7

FK-16

LL-37-derived, synthetic

FKRIVQRIKD FLRNLV

16

 + 5

Buforin I

Frog stomach, histone-derived, Human gastric fluida

AGRGKQGGKV RAKAKTRSSR AGLQFPVGRV HRLLRKGNY a

39

 + 13

Dhvar4

Human saliva histatin-derived synthetic

KRLFKKLLFS LRKY

14

 + 7

Macropin 1

Insect venom

GFGMALKLLK KVL

13

 + 4

Lasioglossin III

Insect venom

VNWKKVLGKI IKVAK

15

 + 3

Temporin-La

Frog skin

LLRHVVKILE KYL

13

 + 6

  1. For helical wheel representation of the peptides see Fig. S1. Note that all peptides are amidated at their C-terminus. Net charge refers to pH 7.
  2. aThis is the bullfrog sequence36, the human variant is SGRGKQGGKA RAKAKT(S)RSSR AGLQFPVGRV HRLLRKGNY according to the uniprot website (https://www.uniprot.org).
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