Figure 2

Heatmap showing individual nasal and oropharyngeal profiles in (A). young (18–55 years, n = 57) and (B) older (> 55 years, n = 55) adults. Participants are colour coded; white squares qPCR-negative, black squares Spn6B + , grey squares lytA + and hatched squares co-colonisers. Data is broken down by age group and gender. More Spn6B + participants were detected in nose (NW) than oropharynx (OPS) in both age groups (Young: NW n = 41 vs OPS n = 36, Older: NW n = 28 vs OPS n = 20). Pneumococcal presence in both NW (Young n = 41 vs Older n = 28, *P = 0.026) and OPS (Young n = 36 vs Older n = 20, **P = 0.008) was statistically significantly different between young and older adults (GLM model). In older adults, fewer Spn6B + participants were detected in saliva (n = 5). Heatmaps were created in Microsoft Excel (2016), Microsoft, USA, www.microsoft.com.