Figure 6

Schematic presentation of the levels of hepatic glucose metabolites and the expression of rate-limiting enzymes of glucose metabolism in Pg- and CMC-treated diabetic mice. Fold changes in the glucose metabolites and enzymes involved in intrahepatic glucose metabolism in the Pg-treated mice, relative to that in the control. Red circles and lines: significant increases. Blue circles and lines: significant reductions. Metabolites that varied substantially and significantly between the Pg-treated mice and the control were identified using these criteria: log₂ fold change >|0.26| and P < 0.05, and P < 0.01. 2 KG, 2-Ketoglutaric acid; 6PG, 6-Phosphogluconic acid; Ace CoA, Acetyl-CoA; BPGA, 1,3-Bisphosphoglycerate; Cit, Citric acid; DHAP, Dihydroxyacetone phosphate; F1P, d-Fructose 1-phosphate; F6P, d-Fructose 6-phosphate; Frc, d-Fructose; G1P, d-Glucose 1-phosphate; G6P, d-Glucose 6-phosphate; GAP, Glyceraldehyde 3-phosphate; Glc, d-Glucose; Isocit, Isocitric acid; Lac, Lactic acid; MAL, Malic acid; Oxa, Oxaloacetic acid; PEP, Phosphoenolpyruvic acid; PGA, 2-Phospho-d-glyceric acid/3-Phospho-d-glyceric acid; Pyr, Pyruvic acid; Suc, Succinic acid; Suc CoA, Succinyl-CoA; UDP-Gal, UDP-alpha-d-galactose; UDP-Glc, Uridine 5′-diphosphate glucose; AGL, Amylo-1,6-glucosidase, 4-alpha-glucanotransferase; Aldoa, Fructose-bisphosphate aldolase A; Dlat, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Pdhb, Pyruvate dehydrogenase E1 component subunit beta; Fh1, Fumarate hydratase-1; Gpi1, Glucose-6-phosphate isomerase 1; Gys2: Glycogen [starch] synthase 2; Ldha, L-lactate dehydrogenase; Pck1, Phosphoenolpyruvate carboxykinase; Pgm2, Phosphoglucomutase-2; Idh3a, Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Suclg1, Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; Sdhc, Succinate dehydrogenase (ubiquinone) cytochrome b560 subunit; Acly, ATP citrate (pro-S)-lyase; Tpi1, Triosephosphate isomerase 1.