Figure 2 | Scientific Reports

Figure 2

From: Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells

Figure 2

Scratch wound assay of CSE-treated A549 cells to measure migratory capacity. (a,b) Wound closure rates increased until the 0.5 × dilution setup but a sudden decrease was observed in the concentrated 1 × setup. (c,d) When SCAL1 was knocked down 24 h post-exposure to 0.1 × CSE, wound closure after 16 h was significantly reduced compared to the control. (e,f) SCAL1 overexpression increased wound healing rates while the converse was observed upon (g,h) SCAL1 knockdown. Images shown are representative of three independent trials done in triplicates. Data presented are representative of three independent trials and are expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.

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