Figure 4
From: DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis
Effects of Dapl1 ablation on the production of gonadotropins in the hypothalamic-pituitary system. (A) Effect of Dapl1 ablation on the pituitary expression of mRNA coding for pituitary LHβ, FSHβ, TSHβ and αGSU in male mice at PND49. Each bar represents the mean ± S.E.M. of 11–12 mice. (B) Effect of Dapl1 ablation on the hypothalamus gene-expression of mRNA coding for GnRH and KISS1 in male mice at PND49. Each bar represents the mean ± S.E.M. of 4–5 mice. (C) Effect of Dapl1 ablation on the pituitary gene-expression of mRNA coding for GnRHR and the testicular steroidogenesis gene-expression of mRNA coding for LHR in male mice at PND49. Each bar represents the mean ± S.E.M. of 9–12 mice. Significantly different from the wild-type control: *p < 0.05. DAPL1 death-associated protein-like 1, LHβ luteinizing hormone β subunit, FSHβ follicle-stimulating hormone β subunit, TSHβ thyroid-stimulating hormone β subunit, αGSU glycoprotein hormone α-subunit, GnRH gonadotropin-releasing hormone, KISS1 kisspeptin, GnRHR gonadotropin-releasing hormone receptor, LHR luteinizing hormone receptor, PND49 postnatal day 49.
