Figure 3
Tissue-transcending sex differences and regulation. (A) A barplot indicates how often sex-biased genes are consistent over multiple tissues (female on the left, male on the right). No bar for one sex means that that gene is exclusively sex-biased in the other sex. (B) A barplot shows the sex-biased genes that are sex-biased consistently in at least 6 tissues consistently, with ERAP2 being the top gene for females, and HERC2P7 being the top hit for males. (C) A heatmap shows the normalized enrichment score (NES) of 406 tested motifs for male-biased (top) and female-biased (bottom) genes in at least two tissues. A NES > 3 is considered significantly enriched. (D) A heatmap shows the NES for the top 20 male- and female-biased motifs. (E) A cell identity marker enrichment map is plotted for female-biased genes. The top 30 enrichments are shown, with color indicating for which tissue the enrichment was found, while size indicates the overlapping gene count. (F) A cell identity marker enrichment map is plotted for male-biased genes. The top 30 enrichments are shown, with color indicating for which tissue the enrichment was found, while size indicates the overlapping gene count.
