Figure 4
Importance of sex-biased co-expression exemplified by disease and FDA-approved drugs. (A) A heatmap shows the enrichment for female-biased genes over sex-biased disease such as autoimmune disease and non-reproductive cancer. Disease are shown in the rows, while the tissues are placed on the columns. Color and size of dot indicate –log10 p-value. (B) A heatmap shows the enrichment for male-biased genes over sex-biased disease such as autoimmune disease and non-reproductive cancer. Disease are shown in the rows, while the tissues are placed on the columns. Color and size of dot indicate – log10 p-value. (C) A venn-diagram highlights the overlap between disease-associated genes and gene targets of FDA-approved drugs. (D) A density-plot of amount of genes overlapping shows the permuted distribution of random genes and their overlap with disease genes. The vertical line highlights the observed value for sex-biased genes. (E) A density-plot of amount of genes overlapping shows the permuted distribution of random genes and their overlap with FDA-approved drug target genes. The vertical line highlights the observed value for sex-biased genes.
