Table 1 Summary statistics of the discovery and replication samples.
Discovery sample | Replication sample | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
TAU | NET | NET | |||||||||
N = | n = 42 | n = 42 | n = 53 | ||||||||
Reported age | 18 (1.8) | 18 (2) | 34 (9.1) | ||||||||
Trauma perpetrated | 14 (4.9) | 15 (4.7) | 16 (5.2) | ||||||||
Trauma experienced | 15 (1.7) | 15 (1.9) | 34 (5.7) |
BL | FU6 | Cohen's d | BL | FU6 | Cohen's d | BL | FU4 | Cohen's d | FU10 | Cohen's d | |
---|---|---|---|---|---|---|---|---|---|---|---|
Epigenetic age | 21 (5.8) | 21 (5.7) | 0.15 [− 0.21,0.46] | 18 (4.2) | 19 (4.3) | 0.19 [− 0.12,0.5] | 43 (7.2) | 44 (7.9) | 0.19 [− 0.12,0.48] | 44 (7.7) | 0.26 [− 0.04,0.54] |
DNAm (Beta) | 0.61 (0.008) | 0.612 (0.006) | 0.34 [0.04,0.63] | 0.61 (0.008) | 0.611 (0.008) | 0.24 [− 0.09,0.55] | 0.56 (0.01) | 0.56 (0.01) | 0.01 [− 0.28,0.28] | 0.56 (0.01) | 0.04 [− 0.24,0.31] |
PSS-I sumscore* | 38 (9.4) | 22 (14) | − 1.03 [− 1.51,− 0.43] | 39 (8.4) | 17 (14) | − 1.51 [− 1.92,− 1.01] | 16 (4.1) | 7.1 (5.5) | − 1.48 [− 1.95,− 0.9] | 5.9 (5.2) | − 1.56 [− 2,− 0.99] |
PHQ-9 sumscore† | 13 (5.3) | 7 (3.6) | − 1.16 [− 1.48,− 0.79] | 12 (5) | 6.8 (3.8) | − 1.09 [− 1.33,− 0.78] | 13 (9.7) | 7.9 (8.7) | − 0.44 [− 0.75,− 0.08] | 6.6 (7.6) | − 0.53 [− 0.82,− 0.19] |
AAS sumscore | 22 (11) | 10 (12) | − 0.78 [− 1.23,− 0.24] | 26 (11) | 7.6 (7.8) | − 1.5 [− 1.82,− 1.13] | 31 (17) | n.a | n.a | n.a | n.a |
CVB sumscore | 19 (7.1) | 12 (9.1) | − 0.69 [− 1.04,− 0.27] | 20 (5.8) | 7.9 (6.3) | − 1.76 [− 2.16,− 1.25] | n.a | n.a | n.a | n.a | n.a |
AAGS sumscore‡ | − 0.85 (3.3) | 0.28 (3.5) | 0.38 [0.04,0.69] | 0.03 (3.4) | 0.94 (3.9) | 0.2 [− 0.12,0.52] | n.a | n.a | n.a | n.a | n.a |
SAQ sumscore | 13 (8.8) | 23 (10) | 0.87 [0.51,1.2] | 13 (8.9) | 29 (10) | 1.53 [1.03,1.93] | n.a | n.a | n.a | n.a | n.a |