Table 1 Summary statistics of the discovery and replication samples.

From: DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

 

Discovery sample

Replication sample

TAU

NET

NET

N = 

n = 42

n = 42

n = 53

Reported age

18 (1.8)

18 (2)

34 (9.1)

Trauma perpetrated

14 (4.9)

15 (4.7)

16 (5.2)

Trauma experienced

15 (1.7)

15 (1.9)

34 (5.7)

 

BL

FU6

Cohen's d

BL

FU6

Cohen's d

BL

FU4

Cohen's d

FU10

Cohen's d

Epigenetic age

21 (5.8)

21 (5.7)

0.15 [− 0.21,0.46]

18 (4.2)

19 (4.3)

0.19 [− 0.12,0.5]

43 (7.2)

44 (7.9)

0.19 [− 0.12,0.48]

44 (7.7)

0.26 [− 0.04,0.54]

DNAm (Beta)

0.61 (0.008)

0.612 (0.006)

0.34 [0.04,0.63]

0.61 (0.008)

0.611 (0.008)

0.24 [− 0.09,0.55]

0.56 (0.01)

0.56 (0.01)

0.01 [− 0.28,0.28]

0.56 (0.01)

0.04 [− 0.24,0.31]

PSS-I sumscore*

38 (9.4)

22 (14)

− 1.03 [− 1.51,− 0.43]

39 (8.4)

17 (14)

− 1.51 [− 1.92,− 1.01]

16 (4.1)

7.1 (5.5)

− 1.48 [− 1.95,− 0.9]

5.9 (5.2)

− 1.56 [− 2,− 0.99]

PHQ-9 sumscore†

13 (5.3)

7 (3.6)

− 1.16 [− 1.48,− 0.79]

12 (5)

6.8 (3.8)

− 1.09 [− 1.33,− 0.78]

13 (9.7)

7.9 (8.7)

− 0.44 [− 0.75,− 0.08]

6.6 (7.6)

− 0.53 [− 0.82,− 0.19]

AAS sumscore

22 (11)

10 (12)

− 0.78 [− 1.23,− 0.24]

26 (11)

7.6 (7.8)

− 1.5 [− 1.82,− 1.13]

31 (17)

n.a

n.a

n.a

n.a

CVB sumscore

19 (7.1)

12 (9.1)

− 0.69 [− 1.04,− 0.27]

20 (5.8)

7.9 (6.3)

− 1.76 [− 2.16,− 1.25]

n.a

n.a

n.a

n.a

n.a

AAGS sumscore‡

− 0.85 (3.3)

0.28 (3.5)

0.38 [0.04,0.69]

0.03 (3.4)

0.94 (3.9)

0.2 [− 0.12,0.52]

n.a

n.a

n.a

n.a

n.a

SAQ sumscore

13 (8.8)

23 (10)

0.87 [0.51,1.2]

13 (8.9)

29 (10)

1.53 [1.03,1.93]

n.a

n.a

n.a

n.a

n.a

  1. Sample size, reported age, nr. of traumatic events (perpetrated and experienced), epigenetic age, DNAm (Beta), and sumscores for PTSD (PSS-I), depression (PHQ-9), appetitive aggression (AAS), current violent behaviour (CVB), feelings of guilt (AAGS) and social acknowledgement (SAQ) are shown. Except for sample size, all values are reported as means with standard deviations in parentheses. Cohen’s d effect sizes are reported with a 95% bootstrap confidence interval in square brackets.
  2. BL: baseline; FU4,6,10: follow-ups after 4, 6 and 10 months from baseline, respectively; *PDS Scale was used for replication sample; † HSCL Scale was used for replication sample; ‡sumscores of AAGS are scaled; n.a.: not available.