Figure 2 | Scientific Reports

Figure 2

From: Distinguishing feature of gut microbiota in Tibetan highland coronary artery disease patients and its link with diet

Figure 2

Taxonomic analysis of GM alterations in different groups. (a) The proportion of the first 5 dominant phyla of GM in each individual is displayed in the barplot and different phyla are shown in different colors (“circlize” package in R sofware v.3.6.0, https://www.r-project.org/). (b) LEfSe analysis are shown in the barplot (LEfSe sofware v.1.1.0, http://huttenhower.sph.harvard.edu/lefse/). Taxa enriched in different groups are indicated with different color. The horizontal axis is the LDA score, and the vertical axis is the group of microorganisms with significant effects. Only taxa meeting p < 0.05 and LDA > 2 are shown. Taxon abbreviations are added before the bacterium. p phylum, c class, o order, f family, g genus. (c) Cluster box plot compared the differences of the first 8 HTC-enriched genera (average read counts > 100/sample) at the read count level in every two groups in pairs by FDR-adjusted Wilcoxon rank sum test. *p < 0.05 and FDR < 0.05. CAD coronary artery disease, GM gut microbiota, QTP Qinghai-Tibet Plateau, HTC the Tibetan CAD patients residing at QTP, HTN the Tibetan healthy individuals residing at QTP; HHC the Han CAD patients residing at QTP, HHN the Han healthy individuals residing at QTP, LHC the Han CAD patients from sea level in southern China, LHN the Han healthy individuals from sea level in southern China, LDA Linear discriminant analysis, LEfSe LDA coupled with effect size.

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