Table 2 Significant genes in the meta-analyses (significant threshold = 5.7E−07).
From: Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function
Gene | Chr | Smoking status and phenotype Combination | Average # variants across studies (range) | Discovery Stage | Replication Stage (UK BiLEVE) | Replication Stage (UK Biobank) | GTEx | |||
|---|---|---|---|---|---|---|---|---|---|---|
P-value (interaction) | P-value (joint) | P-value (interaction) | P-value (joint) | P-value (interaction) | P-value (joint) | Expressed in lung | ||||
GPR126 | 6 | Current & Ratio | 18.8 (5–25) | 0.40 | 1.9E−09 | 0.61 | 1.1E−16 | 0.54 | 1.4E−30 | Yes |
Ever & Ratio | 0.91 | 2.8E−08 | 0.98 | 1.7E−16 | 0.39 | 5.2E−29 | Yes | |||
PDE3B | 11 | Current & FEV1 | 7.2 (4–9) | 7.1E−06 | 2.9E−07 | 0.94 | 0.37 | 0.25 | 0.44 | Yes |
