Figure 2

Macrophage autophagy deficiency alters the hepatic immune microenvironment after DEN challenge. Number of CD45⁺ cells (A), CD11b⁺ cells (B), neutrophils, Kupffer cells and recruited macrophages (C), CD3⁺, CD4⁺ and CD8⁺ T cells (D), Treg cells (E), NK cells and NKT cells (F) per liver in WT or ATG5^Mye−/− mice 10 months after DEN or saline solution administration. Data are shown as mean ± SEM. *p < 0.05 for WT Control vs WT DEN, # for ATG5^Mye−/− Control vs ATG5^Mye−/− DEN and ^&p < 0.05 for WT vs ATG5^Mye−/−. n = 6–14 for WT mice Control; n = 3–10 for ATG5^Mye−/− mice Control; n = 3–14 for WT mice DEN; n = 4–26 for ATG5^Mye−/− mice DEN.