Figure 5 | Scientific Reports

Figure 5

From: In vivo analysis of onset and progression of retinal degeneration in the Nr2e3rd7/rd7 mouse model of enhanced S-cone sensitivity syndrome

Figure 5

Inflammatory response in aged C57BL/6J Nr2e3rd7/rd7 retinas. Iba1 (left column panels) and F4/80 (middle column panels) antigen staining on C57BL/6J retinas at 13 (A) and 30 months (m) (C), and on C57BL/6J Nr2e3rd7/rd7 retinas at 12 (B) and 26 months (D). All sections were counterstained with DAPI to visualize cell nuclei (right column panels). Note decreased ONL thickness in C57BL/6J Nr2e3rd7/rd7 retinas. Localization of Iba1 positive and F4/80 positive cells in the subretinal space is indicated by white arrows in (B) and (D). CHO: choroid; RPE: retinal pigment epithelium; ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer. Scale bars: 100 µM.

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