Table 2 Binominal logistic regression analysis of maternal smoking and maternal exposure to ETS for predicting offspring’s smaller circumference.

From: Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

Total offsprings (n = 84,856)

Maternal smokinga

Crude model

Adjusted modelc

1

1.000 (reference)

1

1.000 (reference)

2

0.894 (0.812–0.985)

2

0.988 (0.892–1.094)

3

1.032 (0.922–1.156)

3

0.982 (0.868–1.110)

4

1.513 (1.296–1.766)

4

1.653 (1.387–1.969)

Maternal exposure to ETSb

Crude model

Adjusted modelc

1

1.000 (reference)

1

1.000 (reference)

2

1.107 (1.004–1.22)

2

1.066 (0.963–1.181)

3

1.197 (1.083–1.322)

3

1.091 (0.973–1.222)

The offsprings of mothers with “never smoked” (n = 48,381)

Maternal exposure to ETSc

Crude model

Adjusted modeld

1

1.000 (reference)

1

1.000 (reference)

2

1.048 (0.918–1.195)

2

1.017 (0.887–1.166)

3

1.069 (0.908–1.258)

3

1.039 (0.876–1.232)

The offsprings of mothers with “smoking during pregnancy” (n = 3,953)

Number of daily cigarettes

Crude model

Adjusted modelc

 < 5

1.000 (reference)

 < 5

1.000 (reference)

5–9

0.781 (0.503–1.212)

5–9

0.780 (0.496–1.227)

10–14

0.838 (0.549–1.279)

10–14

0.933 (0.602–1.445)

15–19

0.939 (0.535–1.646)

15–19

1.114 (0.627–1.982)

 >  = 20

0.816 (0.466–1.430)

 >  = 20

0.927 (0.517–1.661)

  1. Binominal logistic regression analysis was constructed to evaluate parental smoking for predicting their offspring’s smaller head circumference (HC) (small HC was defined as less than three percentile for their gestational age and sex) in the total offsprings (n = 84,856), in the offsprings of mothers with “never smoked” (n = 48,381), and in the offsprings of mothers with “smoking during pregnancy” (n = 3,953). The values are shown as odds ratios (95% confidence interval). Bold, increasing or decreasing tendency of offspring’s smaller head circumference risk.
  2. a1 = never smoked, 2 = quit before pregnancy, 3 = quit during pregnancy, 4 = smoking during pregnancy.
  3. b1 = seldom, 2 = 1–3 times a week, 3 = 4–7 times a week.
  4. cAdjusted for maternal age, height, pre-pregnancy BMI and parity, maternal alcohol drinking during first to third trimesters, placental weight ratio, and gestational age.