Figure 3
From: Integrated genomics point to immune vulnerabilities in pleural mesothelioma
Histologic features of pleural mesothelioma. (a) Oncoplot of IHC staining and common genomic alterations; three colour coded panels are shown: the upper panel represents the histological subtype of the samples, the middle panel shows antibody staining for the proteins denoted on the left hand side of the panel (antibody staining were assessed as percentages, with the exception of BAP1; representation in the figure was done by grouping samples based on different percentage ranges that are shown in the legend on the right hand side of the panel) and the bottom panel shows any genomic alteration (mutation or copy number alteration) in the analysed samples; (b-e) Representative IHC images for PD-L1, MTAP and BAP1 (100 ×); (f) Analysis on BAP1 genomic and proteomic status by Fishers` exact test; (g) Analysis of MTAP H-score in CDKN2A/MTAP deleted vs CDKN2A/MTAP wild-type by Fisher`s exact test, with a threshold for MTAP H-score set at 50; (h) Spearman correlation between PD-L1 gene expression and IHC.
