Table 1 Dose criteria of RTOG 0933 protocol and additional constraints used in the current study.

From: Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing

 

Per protocol

Variation acceptable

Deviation unacceptable

RTOG 0933 protocol

Whole-brain PTV

D2% ≤ 37.5 Gy

D2% ≤ 40 Gy

D2% > 40 Gy

D98% ≥ 25 Gy

D98% < 25 Gy

V30 Gy ≤ 90%

Hippocampus

D100% ≤ 9 Gy

D100% ≤ 10 Gy

D100% > 10 Gy

Dmax ≤ 16 Gy

Dmax ≤ 17 Gy

Dmax > 17 Gy

Optic nerve and chiasm

Dmax ≤ 37.5 Gy

Dmax ≤ 37.5 Gy

Dmax > 37.5 Gy

Additional constraints

Inner ear

Dmean ≤ 15 Gy

Dmean ≤ 16 Gy

Dmean > 16 Gy

Lens

Dmax ≤ 9 Gy

Dmax ≤ 10 Gy

Dmax > 10 Gy

Eye

Dmean ≤ 11 Gy

Dmean ≤ 12 Gy

Dmean > 12 Gy

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