Figure 5
From: Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy
Drugs antagonizing or mimicking the upstream and downstream nodes associated with gene expression profiles. Gene sets of nodes (WGCNA modules) directly connected to source and sink nodes (M04, M05, M07, M10, M12, and M47), predictive gene lists, and top differentially expressed genes (Top DEGs) were used to probe drug-associated signatures from the connectivity map database. Note that known antiepileptic (Carbamazepine and Valproic acid, in green) and epilepsy-inducing (bethanecol, in red) drugs are enriched in nodes directly connected to source and sink nodes, but not in the predictive or top differentially expressed genes. Blue: therapeutic drugs; orange: pro-disease drugs. The − log10 of the enrichment q value is plotted. The lighter-to-darker shades of blue and orange represent a lower-to-higher enrichment, respectively. See details in the “Method”s and Tables S7 and S8.
