Table 1 Metabolic parameters before and after surgery in RYGBP and sham minipig groups.

From: A pilot study about the development and characterization of a Roux en Y gastric bypass model in obese Yucatan minipigs

Variable

Baseline

POD 7

POD 30

p value

Sham

RYGBP

Sham

RYGBP

Sham

RYGBP

Surgery

Time

Interaction

Baseline

G0 (mmol/L)

4.85 ± 0.05

5.19 ± 0.12

4.82 ± 0.11

4.77 ± 0.13

4.74 ± 0.22

4.69 ± 0.18

0.51

0.13

0.35

I0 (µIU/mL)

53.06 ± 6.85

66.61 ± 28.41

59.19 ± 4.20

49.88 ± 9.21

47.19 ± 7.56

49.58 ± 12.72

0.85

0.72

0.72

HOMA-IR

11.43 ± 1.46

15.56 ± 6.81

12.68 ± 0.99

10.62 ± 2.01

10.12 ± 2.05

10.60 ± 3.11

0.76

0.65

0.65

Oral glucose challenge test (OGTT)

Glucose

AUCGi0-30 (mmol/L/30 min)

24.11 ± 5.12

23.80 ± 7.23

25.62 ± 8.82

65.96 ± 4.26

19.08 ± 2.50

57.80 ± 11.39

 < 0.01

0.03

0.02

Glucose peak (mmol/L)

5.69 ± 0.20

5.91 ± 0.40

6.13 ± 0.57

7.22 ± 0.48

5.24 ± 0.34

6.54 ± 0.36

0.04

0.09

0.39

Insulin

AUCii0-30 (µIU/mL/30 min)

2307.74 ± 385.64

1279.12 ± 589.87

2064.35 ± 457.75

4170.41 ± 1482.02

2113.94 ± 820.94

3022.55 ± 1324.58

0.6

0.05

0.02

Matsuda index

23.64 ± 1.78

28.91 ± 5.92

20.56 ± 2.39

19.26 ± 3.35

31.45 ± 6.78

26.13 ± 6.01

0.93

0.11

0.43

GLP-1

AUCi0-30 (pmol/L/30 min)

26.12 ± 7.19

17.73 ± 11.21

36.30 ± 10.30

469.60 ± 107.23

7.92 ± 4.67

196.43 ± 50.44

 < 0.01

 < 0.01

 < 0.01

Lipid profile

Free fatty acids (mmol/L)

0.67 ± 0.12

0.44 ± 0.18

0.84 ± 0.21

0.66 ± 0.08

0.61 ± 0.09

0.40 ± 0.12

0.22

0.10

0.96

Triglycerides (mmol/L)

0.45 ± 0.05

0.38 ± 0.06

0.64 ± 0.09

0.60 ± 0.13

0.54 ± 0.14

0.36 ± 0.02

0.3

0.06

0.67

Total cholesterol (mmol/L)

2.29 ± 0.10

2.52 ± 0.21

2.01 ± 0.09

1.92 ± 0.15

1.95 ± 0.14

1.86 ± 0.06

0.91

 < 0.01

0.28

HDL(mmol/L)

0.83 ± 0.08

0.95 ± 0.10

0.52 ± 0.03

0.51 ± 0.03

0.62 ± 0.06

0.52 ± 0.03

0.95

 < 0.01

0.24

LDL(mmol/L)

1.26 ± 0.15

1.40 ± 0.21

1.19 ± 0.13

1.13 ± 0.13

1.08 ± 0.14

1.18 ± 0.09

0.73

0.19

0.63

Inflammation

Haptoglobin (g/L)

3.77 ± 0.46

4.42 ± 0.60

4.44 ± 0.35

4.43 ± 0.24

2.42 ± 0.34

2.92 ± 0.36

0.37

 < 0.01

0.64

Back to article page