Figure 2

Comparison of miR and mRNA profiles of the human SAN vs RA. (a) Volcano plot (left) of mRNA profile for paired human SAN and RA (n = 7). Heat map (middle) of significantly different mRNAs for paired SAN and RA. PCA (right) for SAN and RA mRNA samples; each circle represents a single sample. (b) Volcano plot (left) of miR profile for paired human SAN and RA. Heat map (middle) of significantly different miRs for paired SAN and RA. PCA (right) for SAN and RA miR samples; each circle represents an individual sample. (c) Bar graphs show representative significantly different (FDR < 0.05) mRNAs and (d) miRs in the human SAN vs. RA detected by NGS. Plots and heat maps were generated with R 3.6.3. HF indicates heart failure; NGS, next generation sequencing; PCA, principal component analysis; qPCR, quantitative polymerase chain reaction; RA, right atrium; and SAN, sinoatrial node.