Figure 3 | Scientific Reports

Figure 3

From: Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells

Figure 3

Volcano plots of metabolite levels in the attached cells for Met (a), MetDG (b) and HiDG (c) compared to control. Metabolites on the left side of the black line were decrease while those on the right side of the black line were increased in Met (a), MetDG (b) or HiDG (c) compared to CTRL. Y-axis: p values (inverse log scale); x-axis: metabolite ratios (median QC normalized data, log-scaled). Left black dotted line (0.8)—ratio of 0.8; right black dotted line (1.2)—ratio of 1.2. The red line denotes a p value of 0.01, the orange line denotes a p value of 0.05 and the grey line denotes a p value of 0.1. Metabolites are colored according to the HMDB classes. Metabolites with p value bellow 0.05 and metabolite ratio > 1 or < 0.8 are named. Metabolites are marked with circle for decrease and square for increase in Met (a), MetDG (b) or HiDG (c) compared to CTRL.

Back to article page