Table 1 Significant proteins (VIP > 1) in the orthogonal partial least square discriminant analysis (OPLS-DA) model of all three compartments (intracutaneous, subcutaneous and intravenous) that contributed most to the separation between the different time periods.

From: Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study

Protein ID

Gene name

Protein name

Compartment

VIP

P02766

TTR

Transthyretin

Intracutaneous

1.37

P04217

A1BG

Alpha-1B-glycoprotein

Subcutaneous

1.37

P00450

CP

Ceruloplasmin

Subcutaneous

1.35

P02768

ALB

Albumin

Intracutaneous

1.35

P00738;P00739

HP

Haptoglobin/haptoglobin-related protein

Subcutaneous

1.32

P02652

APOA2

Apolipoprotein A-II

Intracutaneous

1.31

P02768

ALB

Albumin

Subcutaneous

1.30

P02763

ORM1

Alpha-1-acid glycoprotein 1

Subcutaneous

1.28

P01042

KNG1

Kininogen-1

Subcutaneous

1.28

P43652

AFM

Afamin

Intracutaneous

1.27

P02652

APOA2

Apolipoprotein A-II

Subcutaneous

1.24

P01011

AACT

Alpha-1-antichymotrypsin

Intravenous

1.24

P02763

ORM1

Alpha-1-acid glycoprotein 1

Intracutaneous

1.23

P02765

AHSG

Alpha-2-HS-glycoprotein

Intravenous

1.23

P02750

LRG1

Leucine-rich alpha-2-glycoprotein

Subcutaneous

1.23

P04217

A1BG

Alpha-1B-glycoprotein

Intracutaneous

1.22

P02766

TTR

Transthyretin

Subcutaneous

1.21

Q96PD5

PGLYRP2

N-acetylmuramoyl-L-alanine amidase

Subcutaneous

1.21

P01011

AACT

Alpha-1-antichymotrypsin

Subcutaneous

1.20

P68871

HBB

Hemoglobin subunit beta

Intracutaneous

1.20

P69905

HBA1

Hemoglobin subunit alpha

Intracutaneous

1.20

P02750

LRG1

Leucine-rich alpha-2-glycoprotein

Intracutaneous

1.20

P02768

ALB

Albumin

Intravenous

1.19

O75882

ATRN

Attractin

Intracutaneous

1.19

P01011

AACT

Alpha-1-antichymotrypsin

Intracutaneous

1.18

P00738;P00739

HP

Haptoglobin/haptoglobin-related protein

Intravenous

1.18

P02766

TTR

Transthyretin

Intravenous

1.15

P25311

AZGP1

Zinc-alpha-2-glycoprotein

Subcutaneous

1.15

P02765

AHSG

Alpha-2-HS-glycoprotein

Subcutaneous

1.15

P02753

RBP4

Retinol-binding protein 4

Intravenous

1.14

P00738;P00739

HP

Haptoglobin/haptoglobin-related protein

Intracutaneous

1.14

P19652

ORM2

Alpha-1-acid glycoprotein 2

Intracutaneous

1.14

P43251

BTD

Biotinidase

Intracutaneous

1.13

P68871

HBB

Hemoglobin subunit beta

Intravenous

1.13

P02765

AHSG

Alpha-2-HS-glycoprotein

Intracutaneous

1.12

P02760

AMBP

Protein AMBP

Intracutaneous

1.11

Q9NZP8

C1RL

Complement C1r subcomponent-like protein

Intracutaneous

1.11

P01019

AGT

Angiotensinogen

Intracutaneous

1.11

P25311

AZGP1

Zinc-alpha-2-glycoprotein

Intracutaneous

1.09

P02763

ORM1

Alpha-1-acid glycoprotein 1

Intravenous

1.09

P00450

CP

Ceruloplasmin

Intracutaneous

1.08

P01009

SERPINA1

Alpha-1-antitrypsin

Intravenous

1.08

P02749

APOH

Beta-2-glycoprotein 1

Intracutaneous

1.08

P01042

KNG1

Kininogen-1

Intracutaneous

1.07

P25311

AZGP1

Zinc-alpha-2-glycoprotein

Intravenous

1.06

P04217

A1BG

Alpha-1B-glycoprotein

Intravenous

1.06

P49454

CENPF

Centromere protein F

Subcutaneous

1.06

O75882

ATRN

Attractin

Intravenous

1.05

P01019

AGT

Angiotensinogen

Intravenous

1.05

Q96PD5

PGLYRP2

N-acetylmuramoyl-L-alanine amidase

Intracutaneous

1.05

Q9NZP8

C1RL

Complement C1r subcomponent-like protein

Subcutaneous

1.04

P02787

TF

Serotransferrin

Intracutaneous

1.04

P02787

TF

Serotransferrin

Subcutaneous

1.01

P02790

HPX

Hemopexin

Intravenous

1.00

  1. Proteins were considered significant if VIP (variable influence of projection) value was > 1. Protein ID (accession number) and gene name are referred to according to the protein database Uniprot (http://uniprot.org).