Figure 1

Macroscopic morphology of 2D-cultured and 3D-cultured TMSCs. (a) Macroscopic morphology of 2D-cultured TMSCs. (b) Macroscopic morphology of 3D-cultured TMSCs. 3D-cultured MSC spheroids had an average size of 182.4 µm on day 1, 169.4 µm on day 2, and 154.1 µm on day 3, and the size of spheroids gradually decreased after 2 days of culture. 2D, two-dimensional; TMSCs, tonsil-derived mesenchymal stem cells.