Figure 3 | Scientific Reports

Figure 3

From: Three-dimensional culture method enhances the therapeutic efficacies of tonsil-derived mesenchymal stem cells in murine chronic colitis model

Figure 3

Disease activity index (DAI) analyzed after treatment with 3D-cultured TMSCs. The DAI scores based on stool consistency, fecal blood, and weight loss significantly decreased in the 3D-TMSC-treated group. *On day 18, the DAI scores in the 3D-TMSC-treated group were significantly lower than those in the DSS + PBS control (P < 0.001), DSS + HEK control (P = 0.013), and 2D-TMSC-treated groups (P = 0.022). **On day 30, the DAI scores in the 3D-TMSC-treated group were significantly lower than those in the DSS + PBS control (P = 0.001), DSS + HEK control (P = 0.010), and 2D-TMSC-treated groups (P = 0.004). 3D, three-dimensional; 2D, two-dimensional; TMSCs, tonsil-derived mesenchymal stem cells; DSS, dextran sulfate sodium; PBS, phosphate-buffered saline; HEK, human embryonic kidney.

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