Table 1 Quantitative results of microCT and histological analysis for skeletal phenotyping in WT vs. 5LOKO mice treated or not with ZL.

From: Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid

Parameters

Sites/groups

WT C

WT ZL

5LOKO C

5LOKO ZL

BV/TV (mm3)

Femur diaphysis

1.808 ± 0.37*#

2.69 ± 0.66#

2.87 ± 1.05*

2.58 ± 0.38

BV/TV (%)

Femur diaphysis

14.21 ± 1.72

24.81 ± 6.23

18.11 ± 5.01

25.98 ± 3.02

Femur metaphysis

10.77 ± 2.69*#&

30.9 ± 7.74#

19.32 ± 4.93*

22.17 ± 2.71&

L5 vertebrae

23.12 ± 5*#&

47.37 ± 23.47#

49.6 ± 9.36*

49.92 ± 12.00&

Tb.Th (mm)

Femur metaphysis

0.17 ± 0.02*#&

0.36 ± 0.04#

0.20 ± 0.02*#

0.28 ± 0.03&#

L5 vertebrae

0.12 ± 0.03*#&

0.27 ± 0.22#

0.20 ± 0.04*

0.25 ± 0.06&

Tb.Sp (mm)

Femur metaphysis

1.09 ± 0.16*#&

0.62 ± 0.17#

0.70 ± 0.07*

0.75 ± 0.12&

Tb.N (1/mm)

Femur metaphysis

0.53 ± 0.17

0.83 ± 0.31

0.83 ± 0.28

0.76 ± 0.12

L5 vertebrae

1.21 ± 0.40

1.86 ± 0.28

2.17 ± 0.27

2.27 ± 0.31

# osteocytes’

Cortical

8.00 ± 3.52

6.18 ± 2.82

5.14 ± 3.02

6.85 ± 2.47

lacunae

Trabecular

10.43 ± 1.51#

2.09 ± 1.57#

6.20 ± 2.68

5.57 ± 1.71

  1. Results are presented as the means (± SD) for each parameter.
  2. In the comparison between columns, symbol* indicates comparison between the effect of 5LO knockout vs. WT; symbol# indicates the effect of ZL treatment in groups of same genotypes (WT vs. WT ZL); and symbol& indicates the effect of ZL treatment in different genotypes (WT vs. 5LOKO). Statistically significant differences are indicated between groups with equal symbols (p < 0.05).
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