Table 2 Histomorphometry for alveolar bone healing in WT vs. 5LOKO aged female mice treated or not with ZL.

From: Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid

Parameters

Period

WT C

WT ZL

5LOKO C

5LOKO ZL

Inflammatory

Infiltrate

7 days

5.53 ± 1.17

14.36 ± 3.93

4.79 ± 1.59

7.67 ± 2.43

21 days

1.62 ± 0.62#

18.33 ± 6.03#&

3.62 ± 1.37#&

10.01 ± 1.51#

Fibers and

Fibroblasts

7 days

24.17 ± 5.89

19.32 ± 12.91

15.60 ± 9.81

23.26 ± 9.41

21 days

11.11 ± 4.12

16.88 ± 3.06

10.74 ± 5.9

22.20 ± 11.12

Bone

Matrix

7 days

21.56 ± 7.91#

7.59 ± 2.11#&

29.71 ± 4.96#&

18.75 ± 3.5#&

21 days

37.24 ± 3.24#

18.83 ± 12.51#

45.67 ± 12.05#

31.18 ± 5.15#

Osteocytes

7 days

6.51 ± 2.06*#

1.06 ± 1.33#&

2.95 ± 0.77*#&

1.09 ± 0.83#

21 days

5.59 ± 3.0024

2.35 ± 2.30

5.75 ± 1.89

3.98 ± 1.24

Empty

Lacunae

7 days

0.025 ± .0.05

1.50 ± 1.29

0.03 ± 0.05

1.00 ± 0.81

21 days

0.04 ± 0.08#

7.43 ± 1.85#

1.10 ± 0.74

3.05 ± 1.76

  1. Results are presented as the means (± SD) for each parameter.
  2. In the comparison between columns, symbol* indicates comparison between the effect of 5LO knockout vs. WT; symbol# indicates the effect of ZL treatment in groups of same genotypes (WT vs. WT ZL); and symbol& indicates the effect of ZL treatment in different genotypes (i.e. WT-ZL vs. 5LOKO-ZL or WT-ZL vs. 5LOKO C ). Statistically significant differences are indicated between groups with equal symbols (p < 0.05).
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