Table 3 Biochemical data.

From: A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease

Variable

Control mice

CKD mice

NPD

NPD

LPD

LA-AAD

Fasting glucose (mmol/L)

4.1 ± 0.2

4.3 ± 0.2

3.2 ± 0.1*

4.5 ± 0.1

Fed glucose (mmol/L)

8.2 ± 0.4

8.8 ± 0.5

6.8 ± 0.5

8.1 ± 0.5

Total cholesterol (mmol/L)

4.0 ± 0.3

3.3 ± 0.4

3.6 ± 0.1

3.9 ± 0.2

Triglycerides (mmol/L)

2.3 ± 0.2

2.7 ± 0.2

1.5 ± 0.2*

3.0 ± 0.2

Plasma proteins (g/L)

46.7 ± 1.9

45.7 ± 1.5

47.8 ± 4.4

46.9 ± 1.9

Serum albumin (g/L)

15.8 ± 0.8

18.9 ± 0.5

18.1 ± 0.5

21.1 ± 0.8

Diuresis (mL/24 h)

1.2 ± 1.0***

3.2 ± 1.6

2.0 ± 0.9*

1.9 ± 0.9*

  1. Data are expressed as mean ± SEM for n = 5–12 animals in each group.
  2. NPD Normoproteic diet, LPD Low protein diet, LA-AAD Low aromatic amino-acids diet, CKD Chronic kidney disease.
  3. *p < 0.05; **p < 0.01; ***p < 0.001 versus CKD-NPD (ANOVA and Dunnett post hoc test).
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