Table 1 Nitrile hydrolysis to amide by copper complex.

From: Role of catalytic nitrile decomposition in tricopper complex mediated direct partial oxidation of methane to methanol

Entry

Substrate concentration (M)

Substrate

Products

H2O2 conversion %a

TON

1

10

90

25

2b

18

> 99

25

3

9.7

0

0

4

15

0

0

5c

18

25

7

6d

9

1

0.3

7

19

2

0.5

  1. Reaction conditions: Each entry includes 57.5 eq (57.5 mmoles) of nitriles (except 2 and 6), H2O2 (1 mmol), Complex (BF4) (0.04 mmol, 4% of H2O2), time (2 h), room temperature.
  2. aConversion calculated based on oxidant (H2O2) as the limiting reagent.
  3. bFCH2CN (30 mmol).
  4. cMalononitrile melts at 32 °C, the reaction was carried out at 35 °C.
  5. dAdiponitrile (15 mmol).
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