Figure 1 | Scientific Reports

Figure 1

From: Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training

Figure 1

Overview of the study design, consisting of five interconnected steps: (A) identification of genetic variants linked to insulin sensitivity index (Si), (B) validation of the corresponding gene candidates in a mouse knock down experiment database, (C) identification of transcriptional signatures in skeletal muscles correlating with baseline Si and ∆Si, (D) integration of genetics and transcriptomics signatures, (E) identification of transcription factors likely to drive the transcriptional signatures linked to ∆Si which led to the identification of MEF2A transcription factor as main driver of the transcriptional profile, and (F) development of a statistical model that can predict ∆Si from the transcriptional state of MEF2A interacting genes.

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