Figure 3 | Scientific Reports

Figure 3

From: Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training

Figure 3

Validation of gene candidates from GWAS analysis in a mouse knock down experiment database. (A) Mouse knockout of DNAL1 and IQCJ (associated with baseline Si) and CAND2 and TGM6 (associated with ∆Si) lead to changes related to metabolism and skeletal muscle development (Padj < 0.05, ns = not significant). Details of each experiment can be found in the IMPC database18. (B) Boxplots detailing significant associations of IQCJ, CAND2 and TGM6 knockouts with measurements from IPGTT (intra-peritoneal glucose tolerance test) experiment in mice, which is analogous to intravenous glucose tolerance test (IVGTT) method used to measure Si in study participants.

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