Table 2 Comparison of UK Biobank cohorts with ulcerative colitis that did/did not undergo bowel resection.

From: Hepatobiliary phenotype of individuals with chronic intestinal disorders

 

Ulcerative colitis

without bowel

resection

n = 3300

Ulcerative colitis

with bowel resection

n = 384

p-value

(univariate analysis)

p-value

(multivariable analysis)

Characteristics

Age (years)

57.5 ± 8.0

58.2 ± 7.3

0.085

 

Women (%)

48

45

0.28

 

BMI (kg/m2)

27.6 ± 4.6

27.0 ± 4.7

0.012

 

Alcohol (g/d)

8.6 ± 10.3

7.3 ± 9.0

0.011

 

Diabetes mellitus (%)

7

10

0.054

 

Liver status

ALT (% of ULN)

55.2 ± 34.2

65.5 ± 43.7

< 0.001

< 0.001

ALT ≥ ULN (%)a

6.6

11.0

0.003

0.002

AST (% of ULN)

63.2 ± 26.1

74.1 ± 59.5

0.001

< 0.001

AST ≥ ULN (%)b

5.0

11.6

< 0.001

< 0.001

GGT (% of ULN)

83.5 ± 115.2

134.1 ± 189.2

< 0.001

< 0.001

GGT ≥ ULN (%)c

18.6

35.1

< 0.001

< 0.001

ALP (% of ULN)

75.9 ± 35.0

105.3 ± 94.4

0.001

< 0.001

ALP ≥ ULN (%)d

14.3

22.3

0.001

< 0.001

ICD10 codes

Cholelithiasise

5.12

13.02

< 0.001

< 0.001

Cholangitisf

1.09

2.34

< 0.001

< 0.001

  1. Quantitative measures are expressed as mean with standard deviation or relative frequency (%). All analyses were adjusted for age, sex, BMI, presence of diabetes mellitus, and mean alcohol consumption. p-values <0.05 are highlighted in bold. aunadjusted OR = 1.73[1.21–2.48], adjusted OR = 1.83[1.25–2.67]; bunadjusted OR = 2.49[1.73–3.59], adjusted OR = 2.45[1.69–3.53]; cunadjustedOR = 2.36[1.86–3.00], adjusted OR = 2.64[2.06–3.38]; dOR = 1.71[1.31–2.24], adjusted OR = 1.90[1.43–2.54]; eunadjusted OR = 3.20[1.85–5.54], adjusted OR = 2.89[2.05–4.07]; funadjusted OR = 2.77[1.98–3.88], adjusted OR = 3.19[1.84–5.52].
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