Figure 6 | Scientific Reports

Figure 6

From: Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice

Figure 6

Characterization of the point mutants rPRVABC59 prML146F and rNIID123 prMF146L in mice. (a,b) IFNAR1-KO mice (6 mice/virus group) inoculated with rPRVABC59,rPRVABC59 prML146F, rNIID123 and rNIID123 prMF146L via the footpad were divided into two subgroups (3 mice/subgroup; 1-, 3-, and 6-days post-infection group and 2-, 4-, and 8-days post-infection group) and blood was collected at the indicated time points. Means + standard deviations are shown. (a) rPRVABC59 and rPRVABC59 prML146F. (b) rNIID123 and rNIID123 prMF146L. (c) Testis weight at 6 weeks post infection. (d) Ratios of atrophied to total testes in mice infected with the indicated viruses. (e,f) Viral RNA copy numbers in testes (e) and serum (f) at 6 weeks post infection. Dotted line: limit of detection.

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